Gene and CAR-T cell therapy Directory

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Research and development
in vitro

Preclinical development
in vivo

Manufacturing and clinical trials

Patient

Target Identification arrow_drop_down
  • Gene / protein discovery arrow_right
    • bioinformatics design
  • Expression and pathway analysis of target arrow_right
    • quantification of target
  • Assay development in in-vitro & in-vivo models
  • Research exploratory companion biomarkers
Gene Cloning arrow_drop_down
  • Gene augmentation
  • Gene inhibition
  • Killing Gene
  • KI / KO
  • (Gene) engineering
  • CRISPR activation
  • CRISPR interference
  • TRAC gene editing
  • TALEN
Gene Delivery System arrow_drop_down
  • Lentivirus
  • Other Retrovirus
  • Adeno-Associated Virus (AAV)
  • Adenovirus (ADV)
  • Gene Gun
  • Electroporation
  • Lipid chemical methods
  • Protein chemical methods
  • Mixed chemical methods
  • Inorganic methods
Biomarker Identification arrow_drop_down
  • Research exploratory Companion biomarkers arrow_right
    • Bioinformatics design
    • Bioinformatics prediction & analysis
Binder Generation arrow_drop_down
  • Mouse immunization
  • Phage Display
  • In silico
  • Hybridoma
CAR Construction arrow_drop_down
  • Intracellular Domain
  • T-cell activation/transduction
  • Engineering arrow_right
    • Tandem CAR
    • iCAR
    • Ab-coupled TCR (ATCR)
    • Modulation of CAR potency
Adoptive T Cell Major Challenges in Solid Tumors arrow_drop_down
  • Tumor/Ag heterogeneity
  • Tumor associated Antigen
  • Microenvironment
  • Delivery/homing
  • Combinations
  • Persistence of CAR-T
  • In vivo proliferation and activation of CAR-T
  • Accessibility of tumor cells
Bioproduction/CMC/Analytical Quality Assessment, Quality Control arrow_drop_down
  • Bioproduction
  • Scale-Up
  • Automated manufacturing
  • Automated high throughput microbioreactor system
  • Supply chain logistics
  • Tracking process
  • Monitoring logistics
  • Non-GMP pilot batch
  • GMP batch
  • Cleaning
  • CGMP
  • Cross contamination
  • Sterility
  • Deviations
  • Quality control
  • Contaminants detection
  • Safety for gene-edited cells arrow_right
    • Translocation
    • anti-nuclease response
    • cytokine-independent growth
Ex Vivo & In Vivo Strategy arrow_drop_down
  • Ex Vivo & In Vivo Strategy
Cell procurement arrow_drop_down
  • Autologous

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Companies

ALLOGENICA

Villeurbanne Cedex, France

Allogenica is a Lyon-based biotechnology company specialized in the development of an emerging class of cancer therapy, called CAR-T cells (Chimeric Antigen Receptor T-cells). Allogenica has developed a bioproduction platform that relies on the manipulation of hematopoietic stem cells and their derivatives with the aim of developing allogenic "off-the-shelf" CAR-T cells. Allogenica will offer the next-generation cancer treatment ready to use, at ...

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Alter Ego biotech

Orgeval, France

We are independant CMC consultants, specialized in Biomanufacturing, providing strategic & operational support to biotech companies.

At early stage:
- You need to anticipate the CMC requirements supporting IND/IMPD
- You plan to scale-up & transfer your process to a CDMO while preserving product representativity
- Your team must integrate the GMP culture to support the development of your product

At late stage :
- You plan to modify you...

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AM-Biotech Consulting

LES ULIS, France

After working several years in different companies (start-up, biotech and big pharma) as CMC expert in recombinant protein and cell therapy, I decided to become consultant in order to help small companies (start-up, R&D, CDMO, Biotech) to develop dedicated innovative therapies by sharing my expertise in CMC such as process optimization, tech transfer and bioproduction (non-GMP and GMP).

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Antineo

Lyon, France

Antineo is a contract research organization providing services in preclinical therapeutic research in oncology We offer services to customers wishing to evaluate the antitumor activity of their compounds in the most relevant models, either as single agents or in combination with standard therapies, as well as in models resistant to conventional treatment. Our services include personalized advice and dedicated expertise to determine the most relev...

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Avantor

Rosny-sous-Bois, France

Avantor® can set your science in motion, accelerating your speed to market. A partnership with Avantor® adds reliability and agility from early-stage development through to cGMP production.  We have a proven track record in innovative process optimization through our industry expertise,  best-in-class products, and single-use solutions. Avantor’s global network offers end-to-end support ensuring we’re ready to help when the world ...

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Bioaster

Lyon, France

BIOASTER is a Technological Research Institute (IRT) that is dedicated to the study of microbiology and infectious diseases, tackling diseases caused by bacteria, viruses, parasites, and fungi. We offer a new approach to R&D, by integrating the principal scientific and technological disciplines, to better share the risks of innovation.

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BIOPHACT

Vigoulet Auzil / Paris, France

Biophact is an independent company committed to support and assist Biotech or Pharma to transform a scientific conception into a pragmatic and feasible drug development plan compliant with the regulatory requirements and the medical need. 35 years of drug development in Big Pharmas provide a clear asset for project building.

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CALIGOS

Saint Sébastien Sur Loire, France

Making Quality your company's DNA Our know-how is based on strong expertise in Quality and project management, and our ability to listen to our customers' needs and propose solutions tailored to their context in terms of deadlines, quality and costs.

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Catalent

Limoges, France

CDMO for large molecule, small molecule , peptides and mRNA vaccine State of the Art Filling Line Capable of Filling Vials,Syringes, and Cartridges

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Cell Easy SAS

Toulouse, France

Cell Easy is a rapidly growing Contract Development and Manufacturing Services organization (CDMO) with a dedicated focus on Advanced Cell Therapies. Established in 2017, Cell Easy's commitment extends beyond development and manufacturing; it also places a strong emphasis on regulatory and analytical aspects.  Our company has achieved significant milestones, such as advancing programs to Phase 2, partnering with top 30 international pha...

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Pre-industrial demonstrator

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AP-HP MEARY Center for Cell and Gene Therapy is a leader in the manufacturing of Advanced Therapy  Medicinal  Products (ATMPs), offering cutting-edge expertise to industrial partners to support and carry out their cell, tissue and gene therapy clinical trials. It supports industrial partners in the technical and regulatory development of their processes.

Pre-industrial demonstrator

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ChemoMetec

Bordeaux, France

ChemoMetec is a worldwide leading manufacturer of cell counting and analysis equipment. We specialize in developing and producing high-precision instrumentation, delivering consistent data for thousands of customers across biotech, pharma and academic segments.We are experiencing exponential growth, as we strive towards our goal to be the number one provider in Life Sciences.Designed, manufactured and tested in Denmark, we build our instruments a...

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CliniSciences

Nanterre, France

CliniSciences is a French company, present in 15 European countries and the United States, with a range of activities:- Distribution of products for research, production and diagnosis- Production of reagents and kits for research and diagnostics- Custom production services (peptides, proteins and antibodies)- Sourcing organic products of human originOur customers are scientists from diagnostic laboratories to the pharmaceutical industry, includin...

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CRODA

Montigny-le-Bretonneux, France

Croda Pharma is a leading partner for the development of excipients and the supply of high purity materials for pharmaceutical formulations. Croda Pharma’s formulation and regulation expertise enables the next generation of drug delivery systems. We offer high purity pharmaceutical excipients to enhance delivery, efficacy, and stability of actives as well as highly performing vaccine adjuvants and in-house formulation expertise to aid in naviga...

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Dassault Systèmes

Vélizy-Villacoublay, France

We are Dassault Systèmes, a software company renowned for our commitment to balancing our actions and environmental impact. With 17,000 strategic partners, we hold the largest market share in the fields of PLM, 3D experience and clinical trial management, serving over 300,000 companies across 12 different industries. Our deep conviction is that expanding and improving the real world through virtual means is essential for building a more sus...

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Digital Pharma Lab

Paris, France

We are an independent digital health consulting firm

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Dominique Dutscher

Bernolsheim, France

French company, European leader in the distribution of scientific products, whether equipment (small and large) or consumables. In the fields of Biology, Chemistry or Cleanrooms.Over 50,000 references in stock in France, deliverable in 24 hours.Present in over 20 countries.

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Dynamic Biosensors GmbH

München, Allemagne

DISCOVER MOLECULAR INTERACTIONS. Dynamic Biosensors develops, produces and supplies instruments and consumables for the advanced analysis of biomolecular interactions on biochips or directly on the individual cell, enabling breakthroughs in drug discovery, life sciences research, cell & gene therapies. The company is headquartered in Munich, Germany, and has offices in the United States, United Kingdom, France, Japan and Singapore.

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ETABLISSEMENT FRANCAIS DU SANG EFS

LA PLAINE ST DENIS, France

Etablissement Français du Sang with its EFS Biooproduction's team is offering a full range of services to make ATMPs accessible to patients for highly unmet medical needs.Based on our 4 pharmaceutical ATMPs production platforms all over France, EFS Bioproduction offers 16 GMP class B-rooms.EFS Bioproduction maintains close collaboration with researchers and clinicians throughout the ATMP development and production process. This collaboratio...

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Eurofins BioPharma Product Testing France, leader in testing and analysis services for the pharmaceutical and biotechnology industries, offers a complete range of quality control, analytical development and research services in the pharmaceutical products sector. With in-depth expertise and high-performance facilities, the company helps customers to guarantee the safety, quality and regulatory compliance of their products, contributing to the adv...

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FEMTO-ST

BESANCON, France

The FEMTO-ST Institute “Franche-Comté Electronics Mechanics Thermal Science and Optics – Sciences and Technologies”, is a joint research institution, which is under the quadruple authority of the Université de Franche-Comté (UFC), the Centre National de la Recherche Scientifique (CNRS), the Ecole Nationale Supérieure de Mécanique et Microtechniques (ENSMM) and the Université de Technologie Belfort-Montbéliard (UTBM).Today, in FEMTO-S...

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FLASH BioSolutions

Toulouse, France

An 18-year-old CDMO, discovering and producing innovative technologies for highly effective and innovative therapeutics. FTX’s knowhow is built on strong scientific inspiration, which offers efficient RNA and DNA transfer solutions for its biopharmaceutical customers.

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Getinge France

MASSY, France

Getinge is a global provider of innovative solutions for life sciences.Our unique expertise enables us to offer equipment (washers, sterilizers, isolators and bioreactors) and sterile transfer solutions mainly for pharmaceutical production, including laboratory applications, but also for other industrial and research applications. With its comprehensive range, Getinge Life Science supports you in preventing contamination and optimizing your biopr...

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ICTA

FONTAINE LES DIJON, France

ICTA is an international full-service CRO offering pharmaceutical and medical device professionals an end-to-end service for their product development in Europe and North America.From early development to post-approval, we provide expert guidance to improve and accelerate the development of your product, and support you across its entire life cycle.

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JC Discovery

Marseille, France

JC Discovery is a CRO offering preclinical services in the field of inflammation, auto-immune diseases and immuno-oncology. With a team of multidisciplinary experts and strategic partnerships in place, we are uniquely positioned to drive innovation through all pre-clinical stages of your drug development journey.

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Julie Canovas, Freelance Consultant

St Sebastien sur Loire, France

After 15 years in the biotech and pharma industries, I decided to create my own freelance organization in May 2023 in order to collaborate with my partners in this specific field anywhere in France. Being fully dedicated in solving your challenges, we will build together tailored solutions, according to your needs, with a pragmatic and holistic reflexion. My 360° approach includes overview of processes, teams as well as global context of yo...

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KatalX

Paris, France

KatalX is the Next-Gen Supply Chain Visibility & Collaboration Platform, empowered by Trusted Analytics & AI. We focus on complex Supply Chains, featured by High Value/High Stakes, typically Life Science. KatalX is designed to help Shippers and Logistics providers get full control over their supply chain end-to-end, while collaborating with Carriers/Customers. Our Unique Value Proposition combines three value drivers:1/ Advanced...

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The Carnot network comprises public research structures, certified by the French Ministry in charge of Research, committed to developing research partnerships that promote innovation in businesses of all sizes – from SMEs to large corporations – and among socio-economic stakeholders. The Carnot Institutes are structured to harness their complementarity and unlock the synergies needed to come up with R&D solutions for tackling the key...

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MadeCELL

Bois-Colombes, France

Founded in January 2020, MadeCELL contributes to the structuring of the bio-production sector by providing those involved in the production of Advanced therapy medicinal products (ATMPs) and Cell therapy products (CTP) with an innovative and powerful software solution, covering the production cycle in the field of cell, gene and tissue engineering therapies.

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Microsynth France

Vaulx-en-Velin, France

Microsynth (founded in 1989) is a leading European company in nucleic acid synthesis & analysis

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Miltenyi Biotec

PARIS, France

Miltenyi Biotec is a German biotechnology company, founded in 1989, that is innovative, independent, and experiencing significant growth under the leadership of its founder and owner. The Miltenyi Biotec group currently comprises over 3,900 employees across nearly 25 countries worldwide, including 850 researchers based at our campus in Bergisch Gladbach near Cologne, Germany.Miltenyi Biotec's portfolio of solutions provides innovative tools for t...

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MTInov

Vandoeuvre-les-Nancy, France

MTInov was created in 2020 from the association of the Cell Therapy and Tissue Bank Unit (UTCT) of the Nancy CHRU and the Bioprocesses and Biomolecules research axis of the Reaction and Process Engineering Laboratory (LRGP) of the CNRS and UL, This platform for studying, optimising and scaling up the production of cell-based biomedicines has expertise in cell culture in stirred bioreactors (monitoring, intensification, modelling, bioreactor desig...

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Nova Biomedical

Les Ulis, France

Nova Biomedical is a global leader in the field of in vitro diagnostics (IVD), distinguished by its international presence and over 40 years of expertise in the development, manufacturing, and commercialization of whole blood analyzers and readers. With a presence in over 100 countries through subsidiaries and distributors, Nova employs over 1,200 professionals worldwide. The company offers a wide range of products, including automated cell cultu...

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Oncodesign Services

Villebon-sur-Yvette, France

Innovative services & quality deliverables to accelerate your research program Oncodesign Services is a contract research organization (CRO) specialized in drug discovery whose mission is to contribute to the discovery of innovative therapies against cancers and serious diseases with high medical needs.

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OZ Biosciences

Marseille, France

OZ Biosciences is a product development company that creates, develops and commercializes delivery systems of bioactive materials (DNA, siRNA, proteins, antibodies...), intended for the worldwide scientific community and pharmaceutical industries. Our mission is to assist scientists to accelerate the rhythm of discoveries by offering them technologically advanced tools such as transfection reagents and other life science research products.

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Parean Biotechnologies is a next generation service provider, dedicated to oncology and immune related diseases.Co-founded by 3 scientists, experts immunology, datascience and biotech, Parean supports discovery, preclinical phases, and ancillary studies during clinical trialsParean Biotechnologies provides cutting edge services, to biotech, pharma companies and academics., to charaterize immune and tumor cells, using cytometry, cell sorting, omic...

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PathoQuest

Paris, France

PathoQuest is a global CRO that specializes in biologics quality testing based on next-generation sequencing (NGS) for viral safety and genetic characterization. The company’s proprietary NGS-based testing approach delivers actionable Quality Control reports to the biopharmaceutical industry for cell & gene therapy, vaccines and recombinants.
With a proven track record, PathoQuest offers a team of 50 genomic experts over two sites in France (...

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PMT

Besançon, France

PMT is a 250-member competitive cluster that federates and drives the healthcare technology sector in Burgundy-Franche-Comté through its PMT Santé Cluster, particularly in medtech and biotherapies-bioproduction, with 130 members active in healthtech. The cluster's members combine strong skills in high-level engineering (automation, AI, microfluidics, photonics, etc.), regulatory skills and the development of advanced therapy medicinal products.

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Promega France

Charbonnières-les-Bains, France

Promega, an independent and innovative life sciences company, stands out for its R&D-focused approach, with over 500 active patents.
Founded over 45 years ago, Promega has established itself as a key player in biotechnology, generating Bioluminescence technologies particularly used in Drug Discovery from the exploratory phase through to clinical batch release, as well as in clinical and diagnostic research.
The French branch, located in Charbon...

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PROTEIGENE

Saint Marcel, France

PROTEIGENE is a complete team of sales representatives, product specialists and systems engineers ready to inform and guide you for all your applications in the fields of Cell Biology, Genomics, Biobanking, Metabolomics and Peptide Synthesis.

With 25 years' experience in the sale of consumables and instrumentation, PROTEIGENE can offer you cutting-edge, innovative technologies, as well as the scientific and technical support you need.

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RD-BIOTECH

Besançon, France

RD-BIOTECH is an international CRO/CDMO that provides services in molecular biology, immunology, and cell engineering for both R&D stages and preclinical and clinical development phases of innovative therapy biomolecules: - Plasmid DNA: Cloning and vector construction, pDNA biomanufacturing, Research, High Quality and GMP grades. - Monoclonal and recombinant ANTIBODIES: Biomanufacturing, Research and High Quality grades. - Reco...

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SapioChain

Paris, France

SapioChain offers a portal to record the distribution of pharmaceutical products.
We record data related to the transport of products (T°, position, etc.) regardless of the type and brand of the device; from end to end and through the conditioning changes.
This platform is a simple compliance system. It enables to quickly manage excursions and to choose the right packaging.

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Texcell

Evry Courcouronnes, France

From a service laboratory at the renowned Pasteur Institute in Paris in 1987 to an international contract research organization, Texcell has supported thousands of pharmaceutical and biotech companies in their journey to ensure the safety of their products, from preclinical stages to commercialization. From our roots outside of Paris, Texcell Group has built out a growing network of technical support and laboratory facilities around the worl...

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Thermo Fisher Scientific

Villebon-sur-Yvette, France

As the world leader in serving science, our mission is to enable our customers to make the world healthier, cleaner and safer.

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TRANSPORT SCIENTIFIQUE MEDICAL

CHEMAUDIN ET VAUX, France

Partner of the French Blood Establishment for more than 30 years, and of the main regional health facilities, Transport Scientifique Medical has real expertise in his activity : The sensitive goods transport at temperature directed or ventilated.  (labile blood products, medical biology samples, cellular and tissue products (grafts, stem cell, placental blood, CAR-T, etc.), pharmaceutical products and goods, etc.) With a real flexi...

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ULTRace DP is a "partner" company that assists biotech and start-up companies by providing strategic and operational support where necessary at each and every stage of development, in order to bring their innovative idea/concept or project successfully from the inception phase through to exit or market launch. By combining scientific, pharmaceutical and medical skills, a long track record and extensive development experience (translational r...

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Unither Pharmaceuticals

Paris, France

Unither Pharmaceuticals is a pharmaceutical subcontractor specializing in the development and manufacturing of liquid formulations (including eye drops, saline solutions, asthma medications in BFS single doses, and liquid stick-packs) for originator pharmaceutical companies and generic manufacturers. Currently employing more than 2,150 people in eight manufacturing plants in France, the United States, Brazil and China, Unither Pharmaceuticals has...

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VECTAPLUS

Montpellier, France

Vectaplus was founded by Gabrielle Humphrey to provide CMC consultancy services to biotech and start-ups specialising in ATMPs.
Based in Montpellier France, Vectaplus benefits from an international network of experts in clinical, manufacturing and regulatory affairs to fast-track clinical manufacturing and supply chain operations of innovative therapies.

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WhiteLab Genomics

EVRY-COURCOURONNES, France

WhiteLab Genomics is a pioneering startup leveraging Artificial Intelligence to accelerate and mitigate risks in early-stage research and development pipeline for genomic medicine. We are actively engaged in partnerships with renowned academic institutions (Genethon, Brain Institute), as well as small and mid-sized biotech (Flagship Pioneering, SIREN biotech) and pharmaceutical companies (e.g. Sanofi), aimed at addressing critical challenges in t...

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Yposkesi

Evry, France

Contract and Development Manufacturing Organization specialised in the manufacturing of gene therapy drugs

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Ypso-Facto

Nancy, France

Ypso-Facto has been helping Pharmaceutical and Biopharmaceutical companies optimize their processes since 2014. Our proven methodology combines our/your expertise, well-targeted experiments, and predictive simulation to solve the biggest challenges in (bio)process development.

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