Le réseau des Carnot pour les MTI - The Carnot network for ATMPs
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Contact
France
https://www.lereseaudescarnot.fr/fr/le-reseau-des-carnot-pour-les-medicaments-de-therapie-innovante
Coordinatrice du réseau des Carnot pour les MTI
About us
The Carnot network comprises public research structures, certified by the French Ministry in charge of Research, committed to developing research partnerships that promote innovation in businesses of all sizes – from SMEs to large corporations – and among socio-economic stakeholders.
The Carnot Institutes are structured to harness their complementarity and unlock the synergies needed to come up with R&D solutions for tackling the key challenges facing businesses in different industries.
The Carnot network for for Advanced Therapy Medicinal Products (ATMPs) brings together: AP HP, CALYM, CEA LETI, Chimie Balard Cirimat, Curie Cancer, I2C, Institut du Cerveau, Imagine, OPALE, and Voir & Entendre
Business offer
The Carnot network for ATMPs offers industry agile access to unique advice and solutions to accelerate the R&D of biotherapy innovations.
The Carnot involved cover the full range of biomedical expertise and mastery of the processes and technologies needed to develop cutting-edge biomedicines, biomaterials and devices in various therapeutic fields.
We support our partners across the entire R&D value chain: formulation and synthesis, new therapeutic targets, preclinical validation, imaging, biomarkers, clinical validation, real-life monitoring, bioproduction, biotesting.
Activities
- Research Unit
- Cluster / Association
- Cardiology
- Hematology
- Infectiology
- Immunology
- Inflammation
- Cell origin
- Single donor
- Cell Banking
- IPs
- MSC
- CD34 + HSC cells
- Tissue acquisition
- Apheresis
- Target cell isolation
- iPS reprogramming
- Differentiated Cell
- Safety donor-derived therapies
- Cell modification
- Direct reprogramming
- Cell Activation
- Ex Vivo & In Vivo Strategy
- Ex Vivo & In Vivo Strategy
- Bioproduction engineering
- Cell Expansion
- Stirred tank Bioreactor
- Cell factory
- Microcarrier-based culture
- Organoids culture
- Capsules culture
- Scale-Up
- Process optimization
- Automated manufacturing
- On-line monitoring
- Automated high throughput microbioreactor system
- Non-GMP expansion
- GMP expansion
- Purification/Extraction
- Filtration / microfiltration / ultrafiltration
- Centrifugation
- Chromatography
- CGMP
- Target Identification
- Gene / protein discovery
- Expression and pathway analysis of target
- quantification of target
- Assay development in in-vitro & in-vivo models
- Research exploratory companion biomarkers
- Gene Cloning
- Gene augmentation
- Gene inhibition
- Killing Gene
- KI / KO
- (Gene) engineering
- CRISPR activation
- CRISPR interference
- Gene Delivery System
- Lentivirus
- Other Retrovirus
- Adeno-Associated Virus (AAV)
- Adenovirus (ADV)
- Electroporation
- Lipid chemical methods
- Protein chemical methods
- Mixed chemical methods
- Inorganic methods
- Biomarker Identification
- Research exploratory Companion biomarkers
- Bioinformatics prediction & analysis
- Binder Generation
- Mouse immunization
- Phage Display
- In silico
- Hybridoma
- CAR Construction
- Intracellular Domain
- T-cell activation/transduction
- Engineering
- Tandem CAR
- iCAR
- Ab-coupled TCR (ATCR)
- Modulation of CAR potency
- Adoptive T Cell Major Challenges in Solid Tumors
- Tumor/Ag heterogeneity
- Tumor associated Antigen
- Microenvironment
- Delivery/homing
- Combinations
- Persistence of CAR-T
- In vivo proliferation and activation of CAR-T
- Accessibility of tumor cells
- Cell procurement
- Autologous
- Ex Vivo & In Vivo Strategy
- Ex Vivo & In Vivo Strategy
- Bioproduction/CMC/Analytical Quality Assessment, Quality Control
- Bioproduction
- Scale-Up
- Automated manufacturing
- Automated high throughput microbioreactor system
- Tracking process
- Non-GMP pilot batch
- GMP batch
- Cleaning
- CGMP
- Quality control
