Parean Biotechnologies
keyboard_backspaceBack to Home
Contact
7 allée metis
35400 Saint-Malo
CEO
About us
Parean Biotechnologies is a next generation service provider, dedicated to oncology and immune related diseases.
Co-founded by 3 scientists, experts immunology, datascience and biotech, Parean supports discovery, preclinical phases, and ancillary studies during clinical trials
Parean Biotechnologies provides cutting edge services, to biotech, pharma companies and academics., to charaterize immune and tumor cells, using cytometry, cell sorting, omics bulk and single cell protocols, and advanced bio informatics and bio statistics.
Parean HQ and wet labs are located in Saint-Malo, France, and Datascience Unit in Cochin Institute, Paris.
Parean is ISO 9001, and certified by 10x Genomics.
Business offer
- - Biobanking
- - Cytometry and cell sorting, using standard, and custom panels
- - Immune Repertoire sequencing, B & T cells
- - Transcriptomics sequencing
- - Single Cell omics: Transcriptomics, Cell Surface Protein, Antigen specificity, Immune Repertoire V(d)J, ATACseq
- - BioInformatics & Biostatistics: Omics datascience, with preprocessing, standard, advanced, and custom workflows, including public datasets comparisons.
Activities
- Service
- Genetic Diseases
- Oncology
- Nervous Central System
- Infectiology
- Immunology
- Inflammation
- Target selection & validation
- Gene / protein discovery
- bioinformatics design
- Expression and pathway analysis of target
- quantification of target
- Assay development in in-vitro & in-vivo models
- Research exploratory companion biomarkers
- Hit discovery
- Screening & Identification
- In silico
- Indication searching
- Bioinformatics prediction & analysis
- Immunotherapy lead generation
- Binding & Affinity
- Potency & Specificity
- Epitope mapping
- Pharmacology & Biological activity
- Mode of Action
- Therapeutic efficacy
- Safety
- Immunogenicity
- Hypersensitivity & allergies
- Immunotoxicology
- Specificity
- Manufacturability
- Production quality
- Cell activation
- Avidity testing
- Cell-based activation (APCs, AAPCs)
- Bead-base activation
- Antibody-based activation
- Ex-vivo activation (cell transfer)
- In-vivo activation (in human transgenic mouse models)
- Gene modification / Transduction
- Retroviral & lentiviral vectors
- Transposon/transposase
- mRNA electroporation
- Immunotherapy lead optimization
- Indication Prioritization
- Preclinical biomarkers
- Mechanism/Function
- Mechanism of action
- Safety
- PK/PD features
- Indication Identification
- Exploratory toxicology
- Drug-Target interaction
- Level of response duration
- Specificity
- Surrogate markers
- Research exploratory Companion biomarkers
- Bioinformatics design
- Bioinformatics prediction & analysis
- Animal biomarkers
- Human biomarkers
- Predictive biomarkers
- Treatment efficacy
- Population stratification
- Risk/benefit profile
- Disease progression / follow-up
- Clinical biomarkers
- Predictive biomarkers
- Treatment efficacy
- Population stratification
- Risk/benefit profile
- Disease progression / follow-up
- Safety
- PK/PD features
- Surrogate markers
- Disease progression monitoring
- Companion biomarkers
- Pharmacology
- Treatment efficacy
- Treatment monitoring
- Toxicity
- Bioproduction engineering
- Cell Expansion
- On-line monitoring
- Target Identification
- Gene / protein discovery
- bioinformatics design
- Expression and pathway analysis of target
- quantification of target
- Assay development in in-vitro & in-vivo models
- Research exploratory companion biomarkers
- Biomarker Identification
- Research exploratory Companion biomarkers
- Bioinformatics design
- Bioinformatics prediction & analysis
- Adoptive T Cell Major Challenges in Solid Tumors
- Tumor/Ag heterogeneity
- Tumor associated Antigen
- Microenvironment
- Delivery/homing
- Combinations
- Persistence of CAR-T
- In vivo proliferation and activation of CAR-T
- Accessibility of tumor cells
- Antigen identification, selection, optimization, and validation
- Omics analysis
- In silico modeling
- Structure-based antigen design
- Antigen expression systems
- Antigen characterization
- Pathogen-host knowledge
- Pathogen genetics and mechanism of action
- Biomolecular analysis
- In-vivo expression during pathogen cycle
- Antigen-protective immune-response profile
- Cell mediated immunity response
- T cell assays
- Reactogenicity Assessment
- Research exploratory biomarkers
- efficiency vaccination
- protection correlation
- Challenge test – Gold Standard
- Induced immune response characterization
- Regulatory safety
- Immunotoxicology
- Clinical trials
- Immune monitoring
- Quality control & analytical process monitoring
- Biosafety & Bioanalysis
- Immune response characterization
- Batch release test
- Chemical, physical, biological testing
- Potency assay
