Digital Pharma Lab

Activities

Categories

• Service

Therapeutic applications

• Cardiology
• Genetic Diseases
• Oncology
• Nervous Central System
• Hematology
• Infectiology
• Immunology
• Ophthalmology
• Inflammation

Expertises

Directory of Antibodies, Recombinant proteins and others

• Immunotherapy lead generation
• Biophysical profile
• Binding & Affinity
• Potency & Specificity
• Epitope mapping
• Functional effects
• ADCC, ADCP & CDC
• Antigen density target
• Internalization
• Pharmacology & Biological activity
• PK/PD bioavailability
• Mode of Action
• Therapeutic efficacy
• Safety
• Immunogenicity
• Hypersensitivity & allergies
• Immunotoxicology
• Specificity
• Manufacturability
• Production quality
• CMC feasibility
• Cell activation
• Avidity testing
• Cell-based activation (APCs, AAPCs)
• Bead-base activation
• Antibody-based activation
• Ex-vivo activation (cell transfer)
• In-vivo activation (in human transgenic mouse models)
• Gene modification / Transduction
• Retroviral & lentiviral vectors
• Transposon/transposase
• mRNA electroporation
• CRISPR/Cas9
• Immunotherapy lead optimization
• Engineering
• ADC
• Linkers
• Payloads
• Protein scaffolds
• Fragments
• Multi-, bispecific
• Fc-fusion proteins
• Indication Prioritization
• Antibody humanization
• Affinity maturation
• Proof of concept
• Pharmacology potency
• Exploratory toxicology
• in-vitro & ex-vivo models
• in-vivo models
• Cell expansion
• Gas permeable bags
• G-Rex bioreactors
• Wave-mixed bioreactors
• Preclinical biomarkers
• Mechanism/Function
• Mechanism of action
• Safety
• PK/PD features
• Indication Identification
• Exploratory toxicology
• Drug-Target interaction
• Level of response duration
• Specificity
• Surrogate markers
• Research exploratory Companion biomarkers
• Bioinformatics design
• Bioinformatics prediction & analysis
• Animal biomarkers
• Human biomarkers
• Predictive biomarkers
• Treatment efficacy
• Population stratification
• Risk/benefit profile
• Disease progression / follow-up
• Clinical biomarkers
• Predictive biomarkers
• Treatment efficacy
• Population stratification
• Risk/benefit profile
• Disease progression / follow-up
• Safety
• PK/PD features
• Surrogate markers
• Disease progression monitoring
• Regulatory filing
• Regulatory Filing
• Companion biomarkers
• Pharmacology
• Treatment efficacy
• Treatment monitoring
• Toxicity
• Post-market surveillance
• Post-Market Surveillance
Cell Therapy Directory

• CMC/analytical quality assessment, quality control
• Cleaning
• Cross contamination
• Sterility
• Deviations
• Contaminants detection
• Safety for gene-edited cells
• translocation
• anti-nuclease response
• cytokine-independent growth
• Bioproduction engineering
• Cell Expansion
• Stirred tank Bioreactor
• Wave bioreactor
• Cell factory
• Microcarrier-based culture
• Organoids culture
• Capsules culture
• Scale-Up
• Process optimization
• Automated manufacturing
• On-line monitoring
• Automated high throughput microbioreactor system
• Non-GMP expansion
• GMP expansion
• Other
• Purification/Extraction
• Filtration / microfiltration / ultrafiltration
• Centrifugation
• Chromatography
• CGMP
• Bioproduction modeling
• Metabolic / Kinetic modeling
• Control / command
• Global optimization
• Economic analyses
• Artificial Intelligence tools
• Formulation
• Conditioning
• Storage
• Delivery
• Transport
• Supply chain logistics
• Tracking process
• Monitoring logistics
Gene and CAR-T cell therapy Directory

• Bioproduction/CMC/Analytical Quality Assessment, Quality Control
• Bioproduction
• Scale-Up
• Automated manufacturing
• Automated high throughput microbioreactor system
• Supply chain logistics
• Tracking process
• Monitoring logistics
• Non-GMP pilot batch
• GMP batch
• Cleaning
• CGMP
• Cross contamination
• Sterility
• Deviations
• Quality control
• Contaminants detection
• Safety for gene-edited cells
• Translocation
• anti-nuclease response
• cytokine-independent growth
Prophylactic Vaccines Directory

• Post-market surveillance
• Clinical Trial phase IV
• Immune monitoring