Dominique Dutscher
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Contact
2C, rue de Bruxelles
67170 Bernolsheim
France
Responsable des projets de Thérapies Cellulaire et Génique
About us
French company, European leader in the distribution of scientific products, whether equipment (small and large) or consumables. In the fields of Biology, Chemistry or Cleanrooms.
Over 50,000 references in stock in France, deliverable in 24 hours.
Present in over 20 countries.
Business offer
We are France's leading supplier of consumables and reagents for research, biotech and the pharmaceutical industry.
We also supply the main equipment, from workbenches to freeze-dryers, readers, incubators, storage solutions for all temperatures, centrifuges and safety cabinets....
We also have a specific support service to help START UP get started with their first acquisitions.
Maintenance and temperature monitoring services.
300 people in France, 1000 people in Europe.
Activities
- Service
- Technology Supplier
- Cardiology
- Genetic Diseases
- Oncology
- Nervous Central System
- Hematology
- Infectiology
- Immunology
- Ophthalmology
- Inflammation
- Target selection & validation
- Gene / protein discovery
- Expression and pathway analysis of target
- quantification of target
- Assay development in in-vitro & in-vivo models
- Research exploratory companion biomarkers
- Hit discovery
- Screening & Identification
- Therapeutic libraries
- In silico
- In-vivo models
- In-vitro & ex-vivo models
- Immunotherapy lead generation
- Biophysical profile
- Binding & Affinity
- Potency & Specificity
- Pharmacology & Biological activity
- PK/PD bioavailability
- Mode of Action
- Therapeutic efficacy
- Safety
- Immunogenicity
- Hypersensitivity & allergies
- Immunotoxicology
- Specificity
- Manufacturability
- Production quality
- CMC feasibility
- Cell activation
- Avidity testing
- Cell-based activation (APCs, AAPCs)
- Bead-base activation
- Antibody-based activation
- Ex-vivo activation (cell transfer)
- In-vivo activation (in human transgenic mouse models)
- Gene modification / Transduction
- Retroviral & lentiviral vectors
- Transposon/transposase
- mRNA electroporation
- CRISPR/Cas9
- Preclinical biomarkers
- Mechanism/Function
- Mechanism of action
- PK/PD features
- Exploratory toxicology
- Drug-Target interaction
- Level of response duration
- Surrogate markers
- Research exploratory Companion biomarkers
- Animal biomarkers
- Human biomarkers
- Predictive biomarkers
- Treatment efficacy
- Risk/benefit profile
- Disease progression / follow-up
- Bioproduction
- Batches production type
- Mammalian
- Insect
- Yeast
- Bacterial
- GLP compliance
- GMP compliance
- Pilot Batches
- Tests
- Optimization
- Scale-Up process
- Process optimization & validation
- Volume
- Preclinical / Tox
- Low volume (< 200 L)
- High volume (200 – 2000 L)
- Very high volume (> 2000 L)
- Commercial
- USP (Scale-Up)
- Cell expansion
- Inoculation
- Low volume containers to Bioreactors
- DSP (Recovery)
- Harvest
- Filtration
- Fill & Finish
- Aseptic filling
- Lyophilization
- Batch release
- Storage matter
- Instruction
- Logistic
- Cell cryopreservation
- Controlled-rated freezer
- thaw
- Cell origin
- Single donor
- Pool of donors
- Cell Banking
- IPs
- MSC
- CD34 + HSC cells
- Target cell isolation
- iPS reprogramming
- Differentiated Cell
- Production Cell
- Cell modification
- Direct reprogramming
- Cell Activation
- Ex Vivo & In Vivo Strategy
- Ex Vivo & In Vivo Strategy
- CMC/analytical quality assessment, quality control
- Cleaning
- Cross contamination
- Sterility
- Deviations
- Contaminants detection
- Bioproduction engineering
- Cell Expansion
- Stirred tank Bioreactor
- Cell factory
- Microcarrier-based culture
- Organoids culture
- Scale-Up
- Process optimization
- Automated manufacturing
- Automated high throughput microbioreactor system
- Non-GMP expansion
- GMP expansion
- Purification/Extraction
- Filtration / microfiltration / ultrafiltration
- Centrifugation
- Chromatography
- CGMP
- Bioproduction modeling
- Metabolic / Kinetic modeling
- Global optimization
- Conditioning
- Storage
- Bioproduction/CMC/Analytical Quality Assessment, Quality Control
- Bioproduction
- Scale-Up
- Automated manufacturing
- Pathogen-host knowledge
- Pathogen genetics and mechanism of action
- Biomolecular analysis
- In-vivo expression during pathogen cycle
- Host interaction (infection mechanisms)
- In-vitro and in-vivo models
- Bioproduction GMP
- Vaccine platform type
- Recombinant protein expression
- Synthetic Peptides or oligomers
- Virus-like particles (VLP) and nanoparticle-based carriers
- killed/inactivated virus
- Live attenuated virus
- Viral vector encoding target antigen
- DNA plasmid vaccine
- mRNA vaccine
- Lipid delivery vehicle
- Outer-membrane vesicles (OMV)
- Polysaccharides/ conjugated vaccines
- Other
- Pilot Batches scale
- Process development & optimization
- Scale-Up & Validation
- Manufacturing Volume
- Small volume (< 100 L) adjusted to phase I/II needs: specify volume
- Large volume (100 – 1000 L) adapted for phase III needs
- Commercial supply during life cycle management
- Fill & finish
- Lyophilization
- Quality control & analytical process monitoring
- Biosafety & Bioanalysis
- Toxicology
- Immune response characterization
- Viral safety
- Bioproduction analytical monitoring
- Key and critical process parameters (KCP, CPP)
- Identification
- Monitoring
- Batch release test
- Chemical, physical, biological testing
- Potency assay
- Challenge animal models
- Impurities detection
- Quality control test support
