CliniSciences

Activities

Categories

• Service
• Technology Supplier

Therapeutic applications

• Cardiology
• Genetic Diseases
• Oncology
• Nervous Central System
• Hematology
• Infectiology
• Immunology
• Ophthalmology
• Inflammation

Expertises

Directory of Antibodies, Recombinant proteins and others

• Target selection & validation
• Assay development in in-vitro & in-vivo models
• Research exploratory companion biomarkers
• Hit discovery
• Screening & Identification
• Therapeutic libraries
• In silico
• In-vivo models
• In-vitro & ex-vivo models
• Bioinformatics prediction & analysis
• Immunotherapy lead generation
• Manufacturability
• Production quality
• CMC feasibility
• Cell activation
• Avidity testing
• Cell-based activation (APCs, AAPCs)
• Bead-base activation
• Antibody-based activation
• Ex-vivo activation (cell transfer)
• In-vivo activation (in human transgenic mouse models)
• Gene modification / Transduction
• Retroviral & lentiviral vectors
• Transposon/transposase
• mRNA electroporation
• CRISPR/Cas9
• Immunotherapy lead optimization
• Engineering
• ADC
• Linkers
• Payloads
• Protein scaffolds
• Fragments
• Multi-, bispecific
• Fc-fusion proteins
• Antibody humanization
• Proof of concept
• Pharmacology potency
• Exploratory toxicology
• in-vitro & ex-vivo models
• in-vivo models
• Preclinical biomarkers
• Research exploratory Companion biomarkers
• Human biomarkers
• Predictive biomarkers
• Treatment efficacy
• Population stratification
• CMC
• Master Cell Bank
• Production
• Cell Line development
• Clone selection
• Characterization
• Storage
• Analytical development
• Cell Culture
• Media composition
• Bioreactor conditions
• Gene modification / Transduction
• Retroviral & lentiviral vectors
• Cell expansion
• Stirred tank reactors
• Bioproduction
• Batches production type
• Mammalian
• Insect
• Yeast
• Bacterial
• GLP compliance
• GMP compliance
• Pilot Batches
• Tests
• Optimization
• Scale-Up process
• Process optimization & validation
• Volume
• Preclinical / Tox
• Low volume (< 200 L)
• High volume (200 – 2000 L)
• Fill & Finish
• Aseptic filling
• Lyophilization
• Batch release
• Storage matter
• Instruction
• Logistic
• Cell cryopreservation
• Controlled-rated freezer
• thaw
• Quality assurance, quality control & analytical process
• Stability Assessment
• Physical & chemical profile
• Shear/shaking
• Viscosity
• Photostability
• pH
• Freeze/thaw
• Heat/degradation
• Aggregation
• Cell line analytical development
• Host cell proteins
• Viral clearance
• Contaminants detection
• Clinical trials
• Phase I
• Phase II
• Phase III
• Phase IV
• Clinical biomarkers
• Predictive biomarkers
• Treatment efficacy
• Population stratification
• Risk/benefit profile
• Surrogate markers
• Companion biomarkers
• Treatment efficacy
Cell Therapy Directory

• Cell origin
• Single donor
• Pool of donors
• Cell Banking
• IPs
• MSC
• CD34 + HSC cells
• Tissue acquisition
• Off the shelf
• Apheresis
• Target cell isolation
• iPS reprogramming
• Differentiated Cell
• Production Cell
• Safety donor-derived therapies
• Cell modification
• Direct reprogramming
• Cell Activation
• Ex Vivo & In Vivo Strategy
• Ex Vivo & In Vivo Strategy
• Bioproduction engineering
• Purification/Extraction
• Filtration / microfiltration / ultrafiltration
• Centrifugation
• Chromatography
• Bioproduction modeling
• Metabolic / Kinetic modeling
• Control / command
• Global optimization
• Economic analyses
• Artificial Intelligence tools
• Conditioning
• Storage
• Delivery
• Transport
• Supply chain logistics
• Tracking process
• Monitoring logistics
Gene and CAR-T cell therapy Directory

• Gene Cloning
• Gene augmentation
• Gene inhibition
• Killing Gene
• KI / KO
• (Gene) engineering
• CRISPR activation
• CRISPR interference
• TRAC gene editing
• TALEN
• Gene Delivery System
• Lentivirus
• Other Retrovirus
• Adeno-Associated Virus (AAV)
• Adenovirus (ADV)
• Gene Gun
• Electroporation
• Lipid chemical methods
• Protein chemical methods
• Mixed chemical methods
• Inorganic methods
• Binder Generation
• Mouse immunization
• Hybridoma
• Cell procurement
• Autologous
• Ex Vivo & In Vivo Strategy
• Ex Vivo & In Vivo Strategy
• Bioproduction/CMC/Analytical Quality Assessment, Quality Control
• Bioproduction
Prophylactic Vaccines Directory

• Antigen identification, selection, optimization, and validation
• Antigen characterization
• Antigen optimization:
• Generation of mutants
• Early purification
• Early formulation
• Antigen selection: pathogen sequencing and functional antigens
• Surface glycoproteins
• Strongly immunogenic
• Mutation variability
• Membrane antigens
• Outer-membrane proteins (OMP), toxins
• Internal protein
• Less immunogenic
• Conservative sequence
• Vaccine: antigen format platforms
• Recombinant protein expression
• Bacterial
• Cell
• Fungi
• Synthetic Peptides or oligomers
• Virus-like particles (VLP) and nanoparticle-based carriers
• Viral vector encoding target antigen
• Challenge test – Gold Standard
• In-vitro models
• CMC
• GLP compliance
• for preclinical NCS (non-clinical safety) studies
• viral safety testing
• GMP compliance
• Master Banks (cell and viral as needed)
• manufacturing
• Characterization and testing
• storage
• shipment
• Cell Culture / Fermentation
• media formulation and supply
• Bioreactor conditions (cell in suspension, adherent cell player)
• Ability to work in BSL2 conditions
• Cell expansion
• Single use technology (SUS)
• Wave-mixed bioreactors
• Stirred tank reactors
• Gene modification / Transduction
• Molecular biology
• Expression systems
• Formulation
• Formulation
• Lyophilization
• Regulatory safety
• Regulatory safety tests
• Clinical trials
• Phase I
• Phase II (human challenge trials)
• Phase III (large population pending pathogen prevalence)
• Bioproduction GMP
• Vaccine platform type
• Recombinant protein expression
• Synthetic Peptides or oligomers
• Other
• Fill & finish
• Lyophilization
• Vaccine shipment and distribution
• Storage matter
• Labelling
• Packaging for shipping
• Quality control & analytical process monitoring
• Stability Assessment
• Batch release test
• Chemical, physical, biological testing