Prophylactic Vaccines Directory
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Preclinical development
Process development
Manufacturing & clinical development
Launch
into market
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Omics analysis
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In silico modeling arrow_right
- Structure-based antigen design
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Reverse vaccinology
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Epidemiology analysis
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Antigen expression systems
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Assay development with in-vitro & in-vivo models
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Antigen characterization
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Antigen optimization: arrow_right
- Generation of mutants
- Early purification
- Early formulation
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GLP compliance arrow_right
- for preclinical NCS (non-clinical safety) studies
- viral safety testing
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GMP compliance
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Master Banks (cell and viral as needed) arrow_right
- manufacturing
- Characterization and testing
- storage
- shipment
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Cell Culture / Fermentation arrow_right
- media formulation and supply
- Bioreactor conditions (cell in suspension, adherent cell player)
- Ability to work in BSL2 conditions
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Cell expansion arrow_right
- Single use technology (SUS)
- Wave-mixed bioreactors
- Stirred tank reactors
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Gene modification / Transduction arrow_right
- Molecular biology
- Expression systems
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Surface glycoproteins arrow_right
- Strongly immunogenic
- Mutation variability
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Membrane antigens
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Outer-membrane proteins (OMP), toxins
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Internal protein arrow_right
- Less immunogenic
- Conservative sequence
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Immunogenicity in relevant animal models
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Vaccine platform type arrow_right
- Recombinant protein expression
- Synthetic Peptides or oligomers
- Virus-like particles (VLP) and nanoparticle-based carriers
- killed/inactivated virus
- Live attenuated virus
- Viral vector encoding target antigen
- DNA plasmid vaccine
- mRNA vaccine
- Lipid delivery vehicle
- Outer-membrane vesicles (OMV)
- Polysaccharides/ conjugated vaccines
- Other
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Pilot Batches scale arrow_right
- Process development & optimization
- Scale-Up & Validation
- Comparability characterization protocol
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Manufacturing Volume arrow_right
- Small volume (< 100 L) adjusted to phase I/II needs: specify volume
- Large volume (100 – 1000 L) adapted for phase III needs
- Final scale up volume (> 1000 L) and validation for manufacturing
- Commercial supply during life cycle management
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USP (Scale-Up)
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DSP (Recovery)
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Pathogen genetics and mechanism of action arrow_right
- Biomolecular analysis
- In-vivo expression during pathogen cycle
- Host interaction (infection mechanisms)
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In-vitro and in-vivo models
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Formulation arrow_right
- Adjuvants
- Stabilization
- Excipients
- Vaccines Combination
- Lyophilization
- Shipment Monitoring
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Humoral response characterization: arrow_right
- Antibody dosage
- Functional antibody assays (neutralization, CDC, ADCC)
- Other serological assays
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Cell mediated immunity response arrow_right
- T cell assays
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Reactogenicity Assessment
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Research exploratory biomarkers arrow_right
- efficiency vaccination
- protection correlation
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Route of Administration arrow_right
- Intramuscular route
- intradermal route
- Nasal route
- Mucosal routes
- Other devices: specify
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Delivery/ Encapsulation arrow_right
- Polymeric Nanoparticles
- Lipid Nanoparticles
- Nano emulsions
- Adjuvanted delivery systems
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Recombinant protein expression arrow_right
- Bacterial
- Cell
- Fungi
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Synthetic Peptides or oligomers
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Virus-like particles (VLP) and nanoparticle-based carriers
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Killed/inactivated virus
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Live attenuated virus
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Viral vector encoding target antigen
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DNA plasmid vaccine
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mRNA vaccine
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Lipid delivery vehicle
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Outer-membrane vesicles (OMV)
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Polysaccharides/ conjugated vaccines
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Other
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Lyophilization
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Prefilled syringe
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In-vivo animal models
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Induced immune response characterization
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In-vitro models
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Ex-vivo models
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Storage matter
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Labelling
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Packaging for shipping
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Instruction Label
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Digitalization of bar code
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Cold chain logistics
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Specificity arrow_right
- Human sequence homologies
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Regulatory safety tests
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Viral safety
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Hypersensitivity
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Immunotoxicology
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Stability Assessment
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Biosafety & Bioanalysis arrow_right
- Toxicology
- Immune response characterization
- Viral safety
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Bioproduction analytical monitoring arrow_right
- Key and critical process parameters (KCP, CPP)
- Identification
- Monitoring
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Batch release test arrow_right
- Chemical, physical, biological testing
- Potency assay
- Challenge animal models
- Impurities detection
- Quality control test support
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Phase I
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Phase II (human challenge trials)
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Phase III (large population pending pathogen prevalence)
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Immune monitoring
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Data management
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Regulatory Filing arrow_right
- New Drug Application (IND)
- Investigational Medicinal Product (IMPT) for clinical investigations (EMA)
- Common Technical document (CTD) section 3 (CMC) 4 (NCS) and 5 (Clinics) for submission
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Clinical Trial phase IV
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Immune monitoring
Search
Companies
Alter Ego biotech
Orgeval, France
We are independant CMC consultants, specialized in Biomanufacturing, providing strategic & operational support to biotech companies.
At early stage:
- You need to anticipate the CMC requirements supporting IND/IMPD
- You plan to scale-up & transfer your process to a CDMO while preserving product representativity
- Your team must integrate the GMP culture to support the development of your product
At late stage :
- You plan to modify you...
Service
ANAQUANT
Lyon, France
Anaquant is a private Contract Research Organization (CRO) specialized in protein quantification and identification by Mass Spectrometry (MS) for a better drug development. The company benefits from proprietary technologies and more than 15 years of experience of the laboratory’s team with pharmaceutical and biotechnology companies. As expert and trusted partner, Anaquant provides customized services to companies in the pharmaceutical industry ...
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Avantor
Rosny-sous-Bois, France
Avantor® can set your science in motion, accelerating your speed to market. A partnership with Avantor® adds reliability and agility from early-stage development through to cGMP production. We have a proven track record in innovative process optimization through our industry expertise, best-in-class products, and single-use solutions. Avantor’s global network offers end-to-end support ensuring we’re ready to help when the world ...
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Technology Supplier
Axelys Santé
Malakoff, France
Axelys Santé is a CRO offering a full range of services to pharmaceutical companies, biotechs, medtechs and academic institutions.From clinical development to post-marketing activities, our experts advise and support you at every stage of your project and throughout the life cycle of your healthcare product.
Service
Bioaster
Lyon, France
BIOASTER is a Technological Research Institute (IRT) that is dedicated to the study of microbiology and infectious diseases, tackling diseases caused by bacteria, viruses, parasites, and fungi. We offer a new approach to R&D, by integrating the principal scientific and technological disciplines, to better share the risks of innovation.
Research Unit
CALIGOS
Saint Sébastien Sur Loire, France
Making Quality your company's DNA Our know-how is based on strong expertise in Quality and project management, and our ability to listen to our customers' needs and propose solutions tailored to their context in terms of deadlines, quality and costs.
Service
Catalent
Limoges, France
CDMO for large molecule, small molecule , peptides and mRNA vaccine State of the Art Filling Line Capable of Filling Vials,Syringes, and Cartridges
Therapeutic Product
ChemoMetec
Bordeaux, France
ChemoMetec is a worldwide leading manufacturer of cell counting and analysis equipment. We specialize in developing and producing high-precision instrumentation, delivering consistent data for thousands of customers across biotech, pharma and academic segments.We are experiencing exponential growth, as we strive towards our goal to be the number one provider in Life Sciences.Designed, manufactured and tested in Denmark, we build our instruments a...
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CliniSciences
Nanterre, France
CliniSciences is a French company, present in 15 European countries and the United States, with a range of activities:- Distribution of products for research, production and diagnosis- Production of reagents and kits for research and diagnostics- Custom production services (peptides, proteins and antibodies)- Sourcing organic products of human originOur customers are scientists from diagnostic laboratories to the pharmaceutical industry, includin...
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Technology Supplier
CRODA
Montigny-le-Bretonneux, France
Croda Pharma is a leading partner for the development of excipients and the supply of high purity materials for pharmaceutical formulations. Croda Pharma’s formulation and regulation expertise enables the next generation of drug delivery systems. We offer high purity pharmaceutical excipients to enhance delivery, efficacy, and stability of actives as well as highly performing vaccine adjuvants and in-house formulation expertise to aid in naviga...
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Cryoport Systems
Clermont-Ferrand, France
Cryoport Systems is a comprehensive supply chain partner for the life sciences industry focused on meeting the challenges of the global cell and gene therapy market. We excel in the specialized management of the biopharmaceutical supply chain through our comprehensive offerings in logistics, BioServices and biostorage, cryopreservation, and consulting. Our expansive offerings are fully integrated to create a comprehensive platform that helps...
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Dassault Systèmes
Vélizy-Villacoublay, France
We are Dassault Systèmes, a software company renowned for our commitment to balancing our actions and environmental impact. With 17,000 strategic partners, we hold the largest market share in the fields of PLM, 3D experience and clinical trial management, serving over 300,000 companies across 12 different industries. Our deep conviction is that expanding and improving the real world through virtual means is essential for building a more sus...
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DELPHARM
Boulogne-Billancourt, France
Delpharm is a worldwide leader in contract manufacturing and development of medicines. For over 35 years, Delpharm has built up its position by acquiring manufacturing plants over the years, in particular from big pharmaceutical companies. Delpharm’s plants based in Canada, France, Italy, the Netherlands and Poland produce more than a billion boxes of medicines a year. The company employs more than 6,500 people and has achieved in 202...
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Dominique Dutscher
Bernolsheim, France
French company, European leader in the distribution of scientific products, whether equipment (small and large) or consumables. In the fields of Biology, Chemistry or Cleanrooms.Over 50,000 references in stock in France, deliverable in 24 hours.Present in over 20 countries.
Service
Technology Supplier
Eurofins BioPharma Product Testing France
Lentilly, France
Eurofins BioPharma Product Testing France, leader in testing and analysis services for the pharmaceutical and biotechnology industries, offers a complete range of quality control, analytical development and research services in the pharmaceutical products sector. With in-depth expertise and high-performance facilities, the company helps customers to guarantee the safety, quality and regulatory compliance of their products, contributing to the adv...
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FEMTO-ST
BESANCON, France
The FEMTO-ST Institute “Franche-Comté Electronics Mechanics Thermal Science and Optics – Sciences and Technologies”, is a joint research institution, which is under the quadruple authority of the Université de Franche-Comté (UFC), the Centre National de la Recherche Scientifique (CNRS), the Ecole Nationale Supérieure de Mécanique et Microtechniques (ENSMM) and the Université de Technologie Belfort-Montbéliard (UTBM).Today, in FEMTO-S...
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FLASH BioSolutions
Toulouse, France
An 18-year-old CDMO, discovering and producing innovative technologies for highly effective and innovative therapeutics. FTX’s knowhow is built on strong scientific inspiration, which offers efficient RNA and DNA transfer solutions for its biopharmaceutical customers.
Therapeutic Product
Service
Getinge France
MASSY, France
Getinge is a global provider of innovative solutions for life sciences.Our unique expertise enables us to offer equipment (washers, sterilizers, isolators and bioreactors) and sterile transfer solutions mainly for pharmaceutical production, including laboratory applications, but also for other industrial and research applications. With its comprehensive range, Getinge Life Science supports you in preventing contamination and optimizing your biopr...
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ICTA
FONTAINE LES DIJON, France
ICTA is an international full-service CRO offering pharmaceutical and medical device professionals an end-to-end service for their product development in Europe and North America.From early development to post-approval, we provide expert guidance to improve and accelerate the development of your product, and support you across its entire life cycle.
Service
Inside Therapeutics
Angouleme, France
At InsideTX, we are revolutionizing nanoparticle manufacturing, to unlock the full potential of RNA-LNP medicines.
At the convergence of microfluidics and biotechnology, we strive to provide laboratories, biotech, and pharma companies with the ultimate nanoparticle synthesis capabilities by solving three of the biggest challenges of the RNA-LNP revolution:
- Easing screeening
- ensuring seamless scalability all along the development process...
Technology Supplier
Julie Canovas, Freelance Consultant
St Sebastien sur Loire, France
After 15 years in the biotech and pharma industries, I decided to create my own freelance organization in May 2023 in order to collaborate with my partners in this specific field anywhere in France. Being fully dedicated in solving your challenges, we will build together tailored solutions, according to your needs, with a pragmatic and holistic reflexion. My 360° approach includes overview of processes, teams as well as global context of yo...
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Naobios
Saint-Herblain, France
Naobios is a Contract Development and Manufacturing Organization (CDMO) providing bioprocess development and offering GMP production of clinical batches of BSL2/BSL3 viral vaccines, oncolytic viruses, viral vectors and challenge agents.
Having built up 15 years’ experience in bioprocess development, Naobios helps its clients to bring their drug candidates to clinical stage as rapidly as possible – at the highest level of quality – whilst ...
Service
NIR-INDUSTRY: ProcessControlExpert
Versailles, France
Since 2019, ProcessControlExpert has positioned itself as the first Center of Expertise dedicated to operational excellence in R&D, industrialization and production in the (bio)-pharmaceutical and chemical sectors. Combining the strengths of Inhalexpert, Nir-Industry and Galenisys Pharmaceutical Consultants, we offer unparalleled expertise in QbD development, PAT technologies and analytical method validation.
Commitment: Our mission is to op...
Service
Technology Supplier
Oncodesign Services
Villebon-sur-Yvette, France
Innovative services & quality deliverables to accelerate your research program Oncodesign Services is a contract research organization (CRO) specialized in drug discovery whose mission is to contribute to the discovery of innovative therapies against cancers and serious diseases with high medical needs.
Service
Research Unit
Parean Biotechnologies
Saint-Malo
Parean Biotechnologies is a next generation service provider, dedicated to oncology and immune related diseases.Co-founded by 3 scientists, experts immunology, datascience and biotech, Parean supports discovery, preclinical phases, and ancillary studies during clinical trialsParean Biotechnologies provides cutting edge services, to biotech, pharma companies and academics., to charaterize immune and tumor cells, using cytometry, cell sorting, omic...
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PathoQuest
Paris, France
PathoQuest is a global CRO that specializes in biologics quality testing based on next-generation sequencing (NGS) for viral safety and genetic characterization. The company’s proprietary NGS-based testing approach delivers actionable Quality Control reports to the biopharmaceutical industry for cell & gene therapy, vaccines and recombinants.
With a proven track record, PathoQuest offers a team of 50 genomic experts over two sites in France (...
Service
Promega France
Charbonnières-les-Bains, France
Promega, an independent and innovative life sciences company, stands out for its R&D-focused approach, with over 500 active patents.
Founded over 45 years ago, Promega has established itself as a key player in biotechnology, generating Bioluminescence technologies particularly used in Drug Discovery from the exploratory phase through to clinical batch release, as well as in clinical and diagnostic research.
The French branch, located in Charbon...
Service
Technology Supplier
RD-BIOTECH
Besançon, France
RD-BIOTECH is an international CRO/CDMO that provides services in molecular biology, immunology, and cell engineering for both R&D stages and preclinical and clinical development phases of innovative therapy biomolecules: - Plasmid DNA: Cloning and vector construction, pDNA biomanufacturing, Research, High Quality and GMP grades. - Monoclonal and recombinant ANTIBODIES: Biomanufacturing, Research and High Quality grades. - Reco...
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SapioChain
Paris, France
SapioChain offers a portal to record the distribution of pharmaceutical products.
We record data related to the transport of products (T°, position, etc.) regardless of the type and brand of the device; from end to end and through the conditioning changes.
This platform is a simple compliance system. It enables to quickly manage excursions and to choose the right packaging.
Service
Texcell
Evry Courcouronnes, France
From a service laboratory at the renowned Pasteur Institute in Paris in 1987 to an international contract research organization, Texcell has supported thousands of pharmaceutical and biotech companies in their journey to ensure the safety of their products, from preclinical stages to commercialization. From our roots outside of Paris, Texcell Group has built out a growing network of technical support and laboratory facilities around the worl...
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Thermo Fisher Scientific
Villebon-sur-Yvette, France
As the world leader in serving science, our mission is to enable our customers to make the world healthier, cleaner and safer.
Service
Technology Supplier
TRANSPORT SCIENTIFIQUE MEDICAL
CHEMAUDIN ET VAUX, France
Partner of the French Blood Establishment for more than 30 years, and of the main regional health facilities, Transport Scientifique Medical has real expertise in his activity : The sensitive goods transport at temperature directed or ventilated. (labile blood products, medical biology samples, cellular and tissue products (grafts, stem cell, placental blood, CAR-T, etc.), pharmaceutical products and goods, etc.) With a real flexi...
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ULTRace Development Partner
ORSAY, France
ULTRace DP is a "partner" company that assists biotech and start-up companies by providing strategic and operational support where necessary at each and every stage of development, in order to bring their innovative idea/concept or project successfully from the inception phase through to exit or market launch. By combining scientific, pharmaceutical and medical skills, a long track record and extensive development experience (translational r...
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Unither Pharmaceuticals
Paris, France
Unither Pharmaceuticals is a pharmaceutical subcontractor specializing in the development and manufacturing of liquid formulations (including eye drops, saline solutions, asthma medications in BFS single doses, and liquid stick-packs) for originator pharmaceutical companies and generic manufacturers. Currently employing more than 2,150 people in eight manufacturing plants in France, the United States, Brazil and China, Unither Pharmaceuticals has...
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WhiteLab Genomics
EVRY-COURCOURONNES, France
WhiteLab Genomics is a pioneering startup leveraging Artificial Intelligence to accelerate and mitigate risks in early-stage research and development pipeline for genomic medicine. We are actively engaged in partnerships with renowned academic institutions (Genethon, Brain Institute), as well as small and mid-sized biotech (Flagship Pioneering, SIREN biotech) and pharmaceutical companies (e.g. Sanofi), aimed at addressing critical challenges in t...
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Research Unit
Ypso-Facto
Nancy, France
Ypso-Facto has been helping Pharmaceutical and Biopharmaceutical companies optimize their processes since 2014. Our proven methodology combines our/your expertise, well-targeted experiments, and predictive simulation to solve the biggest challenges in (bio)process development.
Service