The french network of biotherapies
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Discover biotherapies
Directory of Antibodies, Recombinant proteins and others
A recombinant protein therapy is produced through recombinant DNA technology, which involves inserting the DNA encoding the protein into bacterial or mammalian cells, expressing the protein in these cells and then purifying it from them. Many biologics, such as monoclonal antibodies (mAbs), are recombinant protein therapies.
Cell Therapy Directory
Cell therapy is a biotherapeutic strategy in which viable cells are injected, grafted, or implanted into a patient in order to prevent, treat or alleviate a disease. It contains or consists of cells, tissues which have undergone substantial manipulation to modify their biological characteristics, physiological functions, or structural properties. In autologous cell therapy the donor and the recipient are the same person, and thus a “custom” product for each patient, whereas on allogeneic cell therapy the recipient and the donor are different people, whatever the level of transformation, including their derivatives.
Gene and CAR-T cell therapy Directory
Gene therapy is a biotherapeutic strategy that treats or prevents a disease through the transfer of of genetic material into cells and thus correcting the underlying genetic problem. Its active substance contains or constitutes a recombinant nucleic acid administered to humans for the purpose of regulating, repairing, replacing, adding or removing a genetic sequence. The transfer of a gene involves an expression system contained in an administration system called a vector which can be of viral or non-viral origin. Its therapeutic, prophylactic or diagnostic effect depends directly on the recombinant nucleic acid sequence it contains or on the product of the gene expression of this sequence.
Prophylactic Vaccines Directory
Prophylactic vaccine involves introducing antigens into a person’s body. The goal is that the human immune system will create antibodies for those antigens and become immune to the associated illness. By stimulating the body's immune system to recognize the agent as foreign, the immune system can more easily challenge these microorganisms upon subsequent encounters. They are prophylactic in the sense that they are administered to healthy individuals to prevent a disease. There are several types of antigen-delivery systems including, the vaccines that contain either dead or live-attenuated microorganisms, inactivated toxins (Toxoid), protein subunits, and polysaccharide antigens or conjugates. More recently, several innovative vaccines have shaded the light with the emergence of mRNA-based vaccines, DNA-based vaccines, recombinant vectors, etc.
