Contact
135 Av. de Rangueil – Campus de L’INSA Toulouse
31400 Toulouse
France
Cheffe de Projet
About us
TIBH is an industrial integrator for the bioproduction development in the health sector.
It was certified in 2020 and received its renewal in 2022 for five years, as part of the “Stratégie Nationale d’Accélération Biothérapies et Bioproduction” of innovative therapies under the France 2030 program.
TIBH brings together TWB, TBI, and CRITT Bio-Industries, located on the INSA Toulouse campus.
It is the only national health integrator aimed at developing alternatives to traditional bioproduction by using microbial cell factories and developing suitable bioprocesses.
TIBH undertakes several missions:
• Supporting the development of new production pathways for biopharmaceuticals based on industrial biotechnologies;
• Providing its expertise, experience, and know-how in the development of microorganisms, required for the production of proteins, therapeutic antibodies, nucleic acids and active molecules, to project leaders developing technologies for the production of innovative therapies;
• Co-developing technological building blocks with innovative startups and industry players to accelerate and de-risk bioproduction.
Business offer
• DESIGN: Development of enzymatic and microbial biocatalysts
• SCREENING: Exploration of molecular diversity in proteins and enzymes (directed evolution, in silico design), screening methods (selection assays, miniaturization of enzymatic assays), structure/activity relationships
• SYNTHETIC BIOLOGY: Development of industrial chassis – genetic and metabolic engineering on conventional and non-conventional strains
• BIOPROCESSING: Development & optimization of microorganism cultivation processes in bioreactors (50mL to 300L) & post-fermentation processing (separation, concentration, purification, crystallization, lyophilization)
• BIOCATALYSIS: Development of enzymatic catalysis processes
• PLAN & MANAGEMENT of R&D programs
• SUPPORT for development and hosting of START-UPS
Activities
- Pre-industrial demonstrator
- Oncology
- Immunology
- Inflammation
- Target selection & validation
- Gene / protein discovery
- bioinformatics design
- Expression and pathway analysis of target
- quantification of target
- Hit discovery
- Screening & Identification
- Therapeutic libraries
- In-vivo models
- Bioinformatics prediction & analysis
- Bioproduction
- Batches production type
- Yeast
- Bacterial
- Pilot Batches
- Optimization
- Scale-Up process
- Process optimization & validation
- Volume
- Low volume (< 200 L)
- USP (Scale-Up)
- Inoculation
- Low volume containers to Bioreactors
- DSP (Recovery)
- Harvest
- Filtration
- Purification
- Fill & Finish
- Lyophilization
