PROFILEHIT
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Contact
7 rue du Buisson
44680 Sainte-Pazanne
France
CEO/CSO
About us
ProfileHIT is a French CRO exploring the pharmacological properties of new compounds, coming from natural products (algae, mushrooms, plants…), Medicinal Chemistry, Biotechnologies or from Agro-Food Industry.
Business offer
At ProfileHIT, we believe that the first target of your product will be the vascular wall.
In this context, we have developed unique material to elucidate specific questions in vitro that arise in your antibody engineering process. We can together:
- - Map your targets that are also expressed in the peripheral vascular system
- - Assess their antigenic density and the impact of their binding to human endothelium (On/Off-target profiling)
- - Analyze the expression of FcRN along our different vascular territories (find FcRn modulators)
- - Follow the binding, recycling and degradation of your product in vascular cells to learn more about their half-life
Activities
- Service
- Cardiology
- Oncology
- Infectiology
- Immunology
- Inflammation
- Target selection & validation
- Expression and pathway analysis of target
- quantification of target
- Assay development in in-vitro & in-vivo models
- Hit discovery
- Screening & Identification
- Therapeutic libraries
- In-vitro & ex-vivo models
- Indication searching
- Immunotherapy lead generation
- Potency & Specificity
- Epitope mapping
- Functional effects
- ADCC, ADCP & CDC
- Antigen density target
- Internalization
- Pharmacology & Biological activity
- PK/PD bioavailability
- Mode of Action
- Therapeutic efficacy
- Safety
- Immunogenicity
- Hypersensitivity & allergies
- Immunotoxicology
- Specificity
- Preclinical biomarkers
- Mechanism/Function
- Mechanism of action
- Exploratory toxicology
