MAbSilico
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Contact
1 impasse du Palais
37000 Tours
France
CEO
About us
MAbSilico is a TechBio providing an antibody drug design & discovery platform. The company successfully generated high-affinity, epitope-specific humanized antibodies against various targets, including proteins involved in cancer, inflammation, and infectious diseases.
Business offer
MAbSilico provides services for antibody optimization (humanization, affinity maturation, developability), antibody characterization (epitope mapping, affinity prediction, cross-reactivity assessment, sequential identification of critical motifs for developability) and biological validation (cytometry, HTRF and BLI).
The design platform is applied for de novo design of antibody through licensing of the technology.
Activities
- Service
- Oncology
- Target selection & validation
- Gene / protein discovery
- bioinformatics design
- Hit discovery
- Screening & Identification
- Therapeutic libraries
- In silico
- In-vivo models
- In-vitro & ex-vivo models
- Indication searching
- Bioinformatics prediction & analysis
- Immunotherapy lead generation
- Biophysical profile
- Binding & Affinity
- Potency & Specificity
- Epitope mapping
- Functional effects
- ADCC, ADCP & CDC
- Antigen density target
- Internalization
- Pharmacology & Biological activity
- PK/PD bioavailability
- Mode of Action
- Therapeutic efficacy
- Safety
- Immunogenicity
- Hypersensitivity & allergies
- Immunotoxicology
- Specificity
- Manufacturability
- Production quality
- CMC feasibility
- Cell activation
- Avidity testing
- Cell-based activation (APCs, AAPCs)
- Bead-base activation
- Antibody-based activation
- Ex-vivo activation (cell transfer)
- In-vivo activation (in human transgenic mouse models)
- Gene modification / Transduction
- Retroviral & lentiviral vectors
- Transposon/transposase
- mRNA electroporation
- CRISPR/Cas9
- Immunotherapy lead optimization
- Engineering
- ADC
- Linkers
- Payloads
- Protein scaffolds
- Fragments
- Multi-, bispecific
- Fc-fusion proteins
- Indication Prioritization
- Antibody humanization
- Affinity maturation
- Proof of concept
- Pharmacology potency
- Exploratory toxicology
- in-vitro & ex-vivo models
- in-vivo models
- Cell expansion
- Gas permeable bags
- G-Rex bioreactors
- Wave-mixed bioreactors
- Quality assurance, quality control & analytical process
- Stability Assessment
- Physical & chemical profile
- Aggregation
