BE4S

Activities

Categories

• Service

Therapeutic applications

• Cardiology
• Oncology
• Nervous Central System
• Hematology
• Infectiology
• Immunology
• Ophthalmology
• Inflammation

Expertises

Directory of Antibodies, Recombinant proteins and others

• Hit discovery
• Screening & Identification
• Therapeutic libraries
• In silico
• In-vivo models
• In-vitro & ex-vivo models
• Immunotherapy lead generation
• Biophysical profile
• Binding & Affinity
• Potency & Specificity
• Epitope mapping
• Functional effects
• ADCC, ADCP & CDC
• Antigen density target
• Internalization
• Pharmacology & Biological activity
• PK/PD bioavailability
• Mode of Action
• Therapeutic efficacy
• Safety
• Immunogenicity
• Hypersensitivity & allergies
• Immunotoxicology
• Specificity
• Manufacturability
• Production quality
• CMC feasibility
• Cell activation
• Avidity testing
• Cell-based activation (APCs, AAPCs)
• Bead-base activation
• Antibody-based activation
• Ex-vivo activation (cell transfer)
• In-vivo activation (in human transgenic mouse models)
• Immunotherapy lead optimization
• Engineering
• Fragments
• Multi-, bispecific
• Fc-fusion proteins
• Antibody humanization
• Affinity maturation
• Proof of concept
• Pharmacology potency
• Exploratory toxicology
• in-vitro & ex-vivo models
• in-vivo models
• CMC
• GLP compliance
• GLP compliance
• Master Cell Bank
• Production
• Cell Line development
• Clone selection
• Characterization
• Storage
• Analytical development
• Cell Culture
• Media composition
• Bioreactor conditions
• Gene modification / Transduction
• Retroviral & lentiviral vectors
• Cell expansion
• Wave-mixed bioreactors
• Stirred tank reactors
• Bioproduction
• Batches production type
• Mammalian
• Insect
• Yeast
• Bacterial
• GLP compliance
• GMP compliance
• Pilot Batches
• Tests
• Optimization
• Scale-Up process
• Process optimization & validation
• Volume
• Preclinical / Tox
• Low volume (< 200 L)
• High volume (200 – 2000 L)
• USP (Scale-Up)
• Cell expansion
• Inoculation
• Low volume containers to Bioreactors
• DSP (Recovery)
• Harvest
• Filtration
• Purification
• Fill & Finish
• Aseptic filling
• Cell cryopreservation
• Controlled-rated freezer
• thaw
• Quality assurance, quality control & analytical process
• Stability Assessment
• Physical & chemical profile
• Shear/shaking
• Viscosity
• Photostability
• pH
• Freeze/thaw
• Heat/degradation
• Aggregation
• Cell line analytical development
• Host cell proteins
• Viral clearance
• Contaminants detection
• Biosafety & Bioanalysis
• Toxicology
• PK/PD features
• Impurities detection
• Bioproduction analytical test
• Monitoring
• Characterization
• Batch consistency
• Formulation
• Formulation
• Dose
• Stability
• Excipients
• Adjuvants
• Sterilization
• Storage stability
• Delivery
• Route of Administration
• Devices associated