Affilogic
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Contact
24 rue de la rainière
44300 Nantes
France
Chargé de prospection internationale
About us
Affilogic is a private biotech company specialized in discovering and developing Nanofitins® through collaborations with worldwide industry leaders in the pharmaceutical sector.
Business offer
Our Nanofitins®, which are small hyperstable affinity proteins, can be designed as targeted inhibitors, or as vectors for specific addressing of cells and tissues. Affilogic follows the science to any therapeutic area as long as an innovative Nanofitin-based biotherapy can make a difference to meet patients’ needs. Usual systemic routes can be travelled by Nanofitins®, but their intrinsic properties make them amenable to other routes, such as oral route and pulmonary delivery.
Activities
- Therapeutic Product
- Oncology
- Nervous Central System
- Infectiology
- Immunology
- Ophthalmology
- Inflammation
- Target selection & validation
- Gene / protein discovery
- bioinformatics design
- Assay development in in-vitro & in-vivo models
- Hit discovery
- Screening & Identification
- Therapeutic libraries
- In silico
- In-vivo models
- In-vitro & ex-vivo models
- Indication searching
- Bioinformatics prediction & analysis
- Immunotherapy lead generation
- Biophysical profile
- Binding & Affinity
- Potency & Specificity
- Epitope mapping
- Functional effects
- ADCC, ADCP & CDC
- Antigen density target
- Internalization
- Pharmacology & Biological activity
- PK/PD bioavailability
- Mode of Action
- Therapeutic efficacy
- Safety
- Immunogenicity
- Immunotoxicology
- Specificity
- Manufacturability
- Production quality
- CMC feasibility
- Cell activation
- Avidity testing
- Cell-based activation (APCs, AAPCs)
- Antibody-based activation
- Ex-vivo activation (cell transfer)
- In-vivo activation (in human transgenic mouse models)
- Gene modification / Transduction
- Retroviral & lentiviral vectors
- mRNA electroporation
- CRISPR/Cas9
- Immunotherapy lead optimization
- Engineering
- ADC
- Linkers
- Payloads
- Protein scaffolds
- Fragments
- Multi-, bispecific
- Affinity maturation
- Proof of concept
- Pharmacology potency
- Exploratory toxicology
- in-vitro & ex-vivo models
- in-vivo models
- Preclinical biomarkers
- Predictive biomarkers
- Treatment efficacy
- Population stratification
- Risk/benefit profile
- Disease progression / follow-up
- Bioproduction
- Batches production type
- Mammalian
- Bacterial
- Pilot Batches
- Tests
- Optimization
- Scale-Up process
- Process optimization & validation
- Volume
- Preclinical / Tox
- USP (Scale-Up)
- Cell expansion
- Inoculation
- Low volume containers to Bioreactors
- DSP (Recovery)
- Harvest
- Filtration
- Purification
- Fill & Finish
- Lyophilization
- Cell cryopreservation
- thaw
- Quality assurance, quality control & analytical process
- Stability Assessment
- Physical & chemical profile
- pH
- Freeze/thaw
- Heat/degradation
- Aggregation
- Cell line analytical development
- Host cell proteins
- Batch release test
- Chemical, physical, biological test
- Post-production test
- Real-time stability test
- Formulation
- Formulation
- Dose
- Stability
- Lyophilization
- Storage stability
- Delivery
- Route of Administration
- Clinical biomarkers
- Predictive biomarkers
- Population stratification
- Risk/benefit profile
- Disease progression / follow-up
